V-Ease
V-Ease contains flavonoid botanical extracts containing diosmin, rutin, hesperidin and quercetin. These compounds have been shown to strengthen the walls and valves of veins and capillaries. V-ease also help relieve pain and reduce the severity of existing varicose veins and spider veins.*
Ingredients
Does not contain: Wheat, gluten, soy, milk, eggs, fish, crustacean shellfish, tree nuts, peanuts
V-Ease
60 x 500 mg capsules
Actions
• Strengthens weak veins, and promotes healthy, even circulation*
• Builds neuro-mediators*
• Encourages forward blood flow by reinforcing the valves inside veins*
• Strengthens vein walls*
• Increase blood viscosity*
• Relieves haemorrhoid pain*
• Improves vein tonicity*
• Anti-inflammatory*
• Anti-oxidant*
Suggested Use:
2 capsules 2 - 3 x daily
Warning:
Pregnancy. Contraindicated with Warfarin and other anti-coagulants.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Schizonepeta tenuifolia Brig—Jing jie sui
‘The fine powder of the fruit-spike was applied evenly to skin lesions and rubbed until the skin became hot. Mild urticaria was cured after 1-2 applications and severe cases after 2-4 applications. Moreover, compound formulae such as “Jing Fang Baidu Decoction”, and “Wuwei Xiaodu Yin” (Five-Herb Detoxicant Decoction), modified to suit the patients’ needs, were also efficacious in the treatment of allergic dermatitis, pruritus, urticaria, exanthema desquamativum, eczema, and psoriasis.’- Clinical Chinese materia medica. 1st ed.*
Citrus aurantium L.—Zhi Ke
A study into the efficacy of Red Orange extract to counteract UVB-induced damage in human keratinocytes such as inflammation and apoptosis found that the extracts had promising photo-protective qualities (Cimino et al, 2007).*
Sophora japonica L.—Huai hua
A study conducted by Wang et al, 2006 into the cosmetic effects of 25 traditional Chinese herbal medicines found that Sophora japonica was especially potent in terms of free radical scavenging effects and high phenolic contents, making it a strong candidates for cosmetic application.*
Angelica sinensis—Dang gui
Research into the function of anti-oxidation on the skin using the compound extract of Danggui found that it delayed senility and increased vitality (Lu et al, 2007). Another study into the effects of angelica polysaccharide by Song et al, 2007 found that low doses of angelica polysaccharide can promote human scalp hair growth in vitro.*
Carthamus tinctorius L.—Hong hua
A study conducted by Roh et al, 2004 into the effects of safflower (Carthamus tinctorius L.) seeds were evaluated for melanogenesis inhibitory activity It was also found that the compounds N-feruloylserotonin and N-(p-coumaroyl) serotonin strongly inhibited the melanin production of Streptomyces bikiniensis and B16 melanoma cells in comparison with a known melanogenesis inhibitor, arbutin.*
Spider Veins/ Haemorrhoids
People get spider veins because the vein walls and valves become weak due to a lack of neuro-mediators. The "weak vein" is the result of a malfunction of valves inside of the vein that are designed to prevent blood from flowing backward in the vein. When the blood flows backwards, spider veins occur. The most common cause of the blood flowing backwards in the vein comes from a genetic weakness of the vein wall. Some people are simply born with weak veins passed down through their families. Circulating hormones, such as progesterone. These hormones can relax the smooth muscle of the vein wall which needs to be strong to prevent spider veins. Additional causes for weakened, damaged veins, besides blood flowing backwards in the vein are:*
- Pregnancies*
- Excess weight*
- Use of female oral contraceptives*
- Occupations that require a standing position*
The strength of the veins are controlled by several nerve endings. These nerve endings play major roles in the contractile and relaxing response of the vein by releasing chemicals called neuro-mediators. It is important that these neuro-mediators do not breakdown and that a healthy amount is maintained in the veins. This keeps the vein from becoming too relaxed, which prevents varicose and Spider Veins.*
Haemorrhoids
Haemorrhoids (sometimes called piles) are actually varicose veins located near the rectum or anus. Sometimes the distended veinous tissue protrudes beyond the anal opening; other times the swollen vein remains concealed within the rectum, making its presence known only when symptoms such as pain or bleeding develop. Haemorrhoids are fundamentally linked to a loss of vascular integrity. Other contributing factors include constipation; a low-fiber diet; pregnancy; and a sedentary occupation or lifestyle. Certain medical conditions, such as cirrhosis of the liver and anal infections, also may increase the risk of developing haemorrhoids.*
Diosmin and Research:
Diosmin, a flavonoid found in some plant sources, is promoted as a high-quality active ingredient in vein improvement supplements. Women and men suffering from venous disorders, such as varicose veins and spider veins, may especially benefit from Diosmin-based products, according to some clinical studies.*
DIOSMIN is derived either directly from various plant sources or from the flavonoid Hesperidin. Sources suggest that this ingredient has been used and studied in clinical settings since the late 1960s, although it did not gain in popularity in the U.S. until much later.*
Although there are many claims associated with DIOSMIN, it appears to be most frequently linked to formulas capable of providing relief for venous diseases. These may include varicose veins, spider veins and other vascular disorders, many of which may affect the legs as well as other parts of the body.*
Diosmin is thought to strengthen the neuro-mediators in the leg's veins so that the veins are able to prevent blood from flowing back. Weak veins may become strong again, and the appearance of bluish spider veins may begin to diminish. Additionally, this active ingredient is considered useful for both preventing certain venous disorders and correcting them once they occur.*
Diosmin reduces inflammation and increases vein tonicity, two important factors that contribute to haemorrhoids. And taken at larger-than-usual "crisis dose" levels, diosmin also appears to significantly shorten the duration of haemorrhoid bleeding.*
A 2000 Italian study of 66 haemorrhoid patients reported that diosmin decreased pain by 79% and bleeding by 67% during the first week of treatment, followed by an astonishing 98% and 86% reduction in these symptoms by the second week (Diana et al, 2000).*
Other clinical studies involving haemorrhoid patients have shown after hemorrhoid surgery, flavonoids were found to relieve pain, bleeding and other symptoms more rapidly than standard antibiotic/anti-inflammatory treatment alone, with especially significant symptom relief during the first three days after surgery (La Torre & Nicolai, 2004).*
In a 12-week study of 50 pregnant women suffering acute haemorrhoids, micronized diosmin/hesperidin therapy was reported to be a "safe, acceptable, and effective" treatment. Of the patients sampled, 66% obtained relief from acute hemorrhoid symptoms within four days, and significantly fewer patients experienced a relapse of symptoms during the post-birth period (Buckshee, 1997).*
Bleeding time was significantly reduced in patients treated with flavonoids plus a fiber supplement in a study of 162 patients with nonprolapsed haemorrhoids; bleeding subsided in an average of just 3.9 days among the dual-treatment group, versus 10.6 days with fiber alone and 5.6 days for rubber band ligation plus fiber (Ho et al, 2000). A similar study of 100 patients reported that acute bleeding had subsided by the third day of treatment for 80% of patients receiving micronized flavonoids, two days sooner than in patients receiving a placebo (Misra & Parshad, 2000).*
In a study involving laboratory rats, hesperidin and diosmin have been shown to help reduce colonic inflammation and oxidative damage. Hesperidin was also found to improve fluid absorption in the colon, a factor that may reduce colitis (Crespo et al, 1999).*
References
Buckshee K. Micronized flavonoid therapy in internal hemorrhoids of pregnancy. International Journal of Gynecology & Obstetrics (1997). 57(2), 145-151.
Cimino F, Cristani M Saija A, Bonina F P & Virgili F. Protective effects of a red orange extract on UVB-induced damage in human keratinocytes. Biofactors (2007), 30(2), 129-138.
Cestari S H, Bastos J K & Di Stasi L C. Intestinal Anti-Inflammatory Activity of Baccharis dracunculifolia in the Trinitrobenzenesulphonic Acid Model of Rat Colitis. Evidence-Based Complementary and Alternative Medicine (2011), 2011, 9.
Diana G, Catanzaro M, Ferrara A & Ferrari P. Activity of purified diosmin in the treatment of hemorrhoids. La Clinica terapeutica (Clin Ter) (2000). 151(5), 341-344.
Ho Y, Tan M & Seow-Choen F. Micronized purified flavonidic fraction compared favorably with rubber band ligation and fiber alone in the management of bleeding haemorrhoids. Dis Colon Rectum (2000) 43, 66.
La Torre F, Nicolai A P. Clinical use of micronized purified flavonoid fraction for treatment of symptoms after hemorrhoidectomy: results of a randomized, controlled, clinical trial. Dis Colon Rectum (2004) 47, 704–710.
Lu Q, Zhao H & Mu Y. An experimental research on the function of anti-oxidation of skin by cosmetics with the compound extract of Danggui. Zhong Guo Mei Rong Yi Xue (2007), 16(11), 1574-1576.
Misra M C & Parshad. Randomized clinical trial of micronized flavonoids in the early control of bleeding from acute internal haemorrhoids. British Journal of Surgery (2000), 87(7), 833-974.
Roh J S, Han J Y, Kim J H & Hwang J K. Inhibitory effects of active compounds isolated from safflower (Carthamus tinctorius L.) seeds for melanogenesis. Biol Pharm Bull. (2004), 27(12), 1976-1978.
Song J, Liu J, Liu S & Wang J. Effect of angelica polysaccharide on human scalp hair growth in vitro. Zhong Guo Ma Feng Pi Fu Bing Za Zhi (2007), 23(11), 960-962.
Wang K H, Lin R D, Hsu F L, Huang Y H, Chang H C, Huang C Y & Lee M H. Cosmetic applications of selected traditional Chinese herbal medicines. Journal of Ethnopharmacology (2006), 106(3), 353-359.
Wen W, Feng S, Li G, Gao X, Hu S, Chen F, et al 1998. Clinical Chinese materia medica. 1st ed. 1: Henan Science & Technology Press.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Ingredients
Does not contain: Wheat, gluten, soy, milk, eggs, fish, crustacean shellfish, tree nuts, peanuts
V-Ease
60 x 500 mg capsules
Actions
• Strengthens weak veins, and promotes healthy, even circulation*
• Builds neuro-mediators*
• Encourages forward blood flow by reinforcing the valves inside veins*
• Strengthens vein walls*
• Increase blood viscosity*
• Relieves haemorrhoid pain*
• Improves vein tonicity*
• Anti-inflammatory*
• Anti-oxidant*
Suggested Use:
2 capsules 2 - 3 x daily
Warning:
Pregnancy. Contraindicated with Warfarin and other anti-coagulants.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Schizonepeta tenuifolia Brig—Jing jie sui
‘The fine powder of the fruit-spike was applied evenly to skin lesions and rubbed until the skin became hot. Mild urticaria was cured after 1-2 applications and severe cases after 2-4 applications. Moreover, compound formulae such as “Jing Fang Baidu Decoction”, and “Wuwei Xiaodu Yin” (Five-Herb Detoxicant Decoction), modified to suit the patients’ needs, were also efficacious in the treatment of allergic dermatitis, pruritus, urticaria, exanthema desquamativum, eczema, and psoriasis.’- Clinical Chinese materia medica. 1st ed.*
Citrus aurantium L.—Zhi Ke
A study into the efficacy of Red Orange extract to counteract UVB-induced damage in human keratinocytes such as inflammation and apoptosis found that the extracts had promising photo-protective qualities (Cimino et al, 2007).*
Sophora japonica L.—Huai hua
A study conducted by Wang et al, 2006 into the cosmetic effects of 25 traditional Chinese herbal medicines found that Sophora japonica was especially potent in terms of free radical scavenging effects and high phenolic contents, making it a strong candidates for cosmetic application.*
Angelica sinensis—Dang gui
Research into the function of anti-oxidation on the skin using the compound extract of Danggui found that it delayed senility and increased vitality (Lu et al, 2007). Another study into the effects of angelica polysaccharide by Song et al, 2007 found that low doses of angelica polysaccharide can promote human scalp hair growth in vitro.*
Carthamus tinctorius L.—Hong hua
A study conducted by Roh et al, 2004 into the effects of safflower (Carthamus tinctorius L.) seeds were evaluated for melanogenesis inhibitory activity It was also found that the compounds N-feruloylserotonin and N-(p-coumaroyl) serotonin strongly inhibited the melanin production of Streptomyces bikiniensis and B16 melanoma cells in comparison with a known melanogenesis inhibitor, arbutin.*
Spider Veins/ Haemorrhoids
People get spider veins because the vein walls and valves become weak due to a lack of neuro-mediators. The "weak vein" is the result of a malfunction of valves inside of the vein that are designed to prevent blood from flowing backward in the vein. When the blood flows backwards, spider veins occur. The most common cause of the blood flowing backwards in the vein comes from a genetic weakness of the vein wall. Some people are simply born with weak veins passed down through their families. Circulating hormones, such as progesterone. These hormones can relax the smooth muscle of the vein wall which needs to be strong to prevent spider veins. Additional causes for weakened, damaged veins, besides blood flowing backwards in the vein are:*
- Pregnancies*
- Excess weight*
- Use of female oral contraceptives*
- Occupations that require a standing position*
The strength of the veins are controlled by several nerve endings. These nerve endings play major roles in the contractile and relaxing response of the vein by releasing chemicals called neuro-mediators. It is important that these neuro-mediators do not breakdown and that a healthy amount is maintained in the veins. This keeps the vein from becoming too relaxed, which prevents varicose and Spider Veins.*
Haemorrhoids
Haemorrhoids (sometimes called piles) are actually varicose veins located near the rectum or anus. Sometimes the distended veinous tissue protrudes beyond the anal opening; other times the swollen vein remains concealed within the rectum, making its presence known only when symptoms such as pain or bleeding develop. Haemorrhoids are fundamentally linked to a loss of vascular integrity. Other contributing factors include constipation; a low-fiber diet; pregnancy; and a sedentary occupation or lifestyle. Certain medical conditions, such as cirrhosis of the liver and anal infections, also may increase the risk of developing haemorrhoids.*
Diosmin and Research:
Diosmin, a flavonoid found in some plant sources, is promoted as a high-quality active ingredient in vein improvement supplements. Women and men suffering from venous disorders, such as varicose veins and spider veins, may especially benefit from Diosmin-based products, according to some clinical studies.*
DIOSMIN is derived either directly from various plant sources or from the flavonoid Hesperidin. Sources suggest that this ingredient has been used and studied in clinical settings since the late 1960s, although it did not gain in popularity in the U.S. until much later.*
Although there are many claims associated with DIOSMIN, it appears to be most frequently linked to formulas capable of providing relief for venous diseases. These may include varicose veins, spider veins and other vascular disorders, many of which may affect the legs as well as other parts of the body.*
Diosmin is thought to strengthen the neuro-mediators in the leg's veins so that the veins are able to prevent blood from flowing back. Weak veins may become strong again, and the appearance of bluish spider veins may begin to diminish. Additionally, this active ingredient is considered useful for both preventing certain venous disorders and correcting them once they occur.*
Diosmin reduces inflammation and increases vein tonicity, two important factors that contribute to haemorrhoids. And taken at larger-than-usual "crisis dose" levels, diosmin also appears to significantly shorten the duration of haemorrhoid bleeding.*
A 2000 Italian study of 66 haemorrhoid patients reported that diosmin decreased pain by 79% and bleeding by 67% during the first week of treatment, followed by an astonishing 98% and 86% reduction in these symptoms by the second week (Diana et al, 2000).*
Other clinical studies involving haemorrhoid patients have shown after hemorrhoid surgery, flavonoids were found to relieve pain, bleeding and other symptoms more rapidly than standard antibiotic/anti-inflammatory treatment alone, with especially significant symptom relief during the first three days after surgery (La Torre & Nicolai, 2004).*
In a 12-week study of 50 pregnant women suffering acute haemorrhoids, micronized diosmin/hesperidin therapy was reported to be a "safe, acceptable, and effective" treatment. Of the patients sampled, 66% obtained relief from acute hemorrhoid symptoms within four days, and significantly fewer patients experienced a relapse of symptoms during the post-birth period (Buckshee, 1997).*
Bleeding time was significantly reduced in patients treated with flavonoids plus a fiber supplement in a study of 162 patients with nonprolapsed haemorrhoids; bleeding subsided in an average of just 3.9 days among the dual-treatment group, versus 10.6 days with fiber alone and 5.6 days for rubber band ligation plus fiber (Ho et al, 2000). A similar study of 100 patients reported that acute bleeding had subsided by the third day of treatment for 80% of patients receiving micronized flavonoids, two days sooner than in patients receiving a placebo (Misra & Parshad, 2000).*
In a study involving laboratory rats, hesperidin and diosmin have been shown to help reduce colonic inflammation and oxidative damage. Hesperidin was also found to improve fluid absorption in the colon, a factor that may reduce colitis (Crespo et al, 1999).*
References
Buckshee K. Micronized flavonoid therapy in internal hemorrhoids of pregnancy. International Journal of Gynecology & Obstetrics (1997). 57(2), 145-151.
Cimino F, Cristani M Saija A, Bonina F P & Virgili F. Protective effects of a red orange extract on UVB-induced damage in human keratinocytes. Biofactors (2007), 30(2), 129-138.
Cestari S H, Bastos J K & Di Stasi L C. Intestinal Anti-Inflammatory Activity of Baccharis dracunculifolia in the Trinitrobenzenesulphonic Acid Model of Rat Colitis. Evidence-Based Complementary and Alternative Medicine (2011), 2011, 9.
Diana G, Catanzaro M, Ferrara A & Ferrari P. Activity of purified diosmin in the treatment of hemorrhoids. La Clinica terapeutica (Clin Ter) (2000). 151(5), 341-344.
Ho Y, Tan M & Seow-Choen F. Micronized purified flavonidic fraction compared favorably with rubber band ligation and fiber alone in the management of bleeding haemorrhoids. Dis Colon Rectum (2000) 43, 66.
La Torre F, Nicolai A P. Clinical use of micronized purified flavonoid fraction for treatment of symptoms after hemorrhoidectomy: results of a randomized, controlled, clinical trial. Dis Colon Rectum (2004) 47, 704–710.
Lu Q, Zhao H & Mu Y. An experimental research on the function of anti-oxidation of skin by cosmetics with the compound extract of Danggui. Zhong Guo Mei Rong Yi Xue (2007), 16(11), 1574-1576.
Misra M C & Parshad. Randomized clinical trial of micronized flavonoids in the early control of bleeding from acute internal haemorrhoids. British Journal of Surgery (2000), 87(7), 833-974.
Roh J S, Han J Y, Kim J H & Hwang J K. Inhibitory effects of active compounds isolated from safflower (Carthamus tinctorius L.) seeds for melanogenesis. Biol Pharm Bull. (2004), 27(12), 1976-1978.
Song J, Liu J, Liu S & Wang J. Effect of angelica polysaccharide on human scalp hair growth in vitro. Zhong Guo Ma Feng Pi Fu Bing Za Zhi (2007), 23(11), 960-962.
Wang K H, Lin R D, Hsu F L, Huang Y H, Chang H C, Huang C Y & Lee M H. Cosmetic applications of selected traditional Chinese herbal medicines. Journal of Ethnopharmacology (2006), 106(3), 353-359.
Wen W, Feng S, Li G, Gao X, Hu S, Chen F, et al 1998. Clinical Chinese materia medica. 1st ed. 1: Henan Science & Technology Press.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.