ThyroCaps
ThyroCaps strengthens thyroid and Increases thyroxine production. ThyroCaps supplies L-Tyrosine for thyroxine production, increases thyroxine production, increases T4 to T3 conversion and increases thermogenesis.*
Supplement FactsServing Size:2 capsules Servings Per Container: 30 |
||
|---|---|---|
|
Amount Per Serving |
% Daily Value |
|
| L-Tyrosine | 350 mg | † |
| Coleus Forskohlii (contains forskolin) | 150mg | † |
| Cordyceps (contains adenosine and mannitol) (Dong Chong Xia Cao) | 340mg | † |
| Guggulipid (contains guggulsterones, E- and Z-guggulsterones) | 160mg | † |
| † Daily Value not established. | ||
Other Ingredients: Vegetable cellulose (hypromellose); Vegetable Stearic Acid; Microcrystalline Cellulose and Vegetable Magnesium Stearate.
Does Not Contain: Wheat, gluten, soy, milk, eggs, fish, crustacean shellfish, tree nuts, peanuts
ThyroCaps
60 x 500mg Vegetarian Capsules
Product Overview
Hypothyroidism, also called under-active thyroid or low thyroid, is a common disorder of the endocrine system. It can cause a number of symptoms, intolerance of cold, fatigue, insomnia, constipation, depression, poor concentration, lowered metabolism, increased menstrual flow, slow heart rate and weight gain. These are very common symptoms but hypothyroidism itself is often undiagnosed. Causes include low iodine levels or Hashimoto's thyroiditis, an autoimmune disease. While the test usually used to diagnose is measuring thyroid-stimulating hormone (TSH), it is not always accurate.*
ThyroCaps supplies L-Tyrosine for thyroxine production, increases thyroxine production, increases T4 to T3 conversion and increases thermogenesis. Among other ingredients ThyroCaps contains an extract of Coleus forskohlii called forskolin, which stimulates the release the thyroid, relieving fatigue, depression, weight gain, and dry skin. Specifically, forskolin is thought to increase thyroid function by activating an enzyme that raises levels of a key cell-regulating substance called cAMP (cyclic adenosine monophosphate).*
Actions
•Supports optimum hormone balance*
•Encourages healthy cellular metabolism*
Suggested Use:
1 to 2 capsules 1 to 2 times daily, maximum 4 daily. Generally, 2 capsules daily is sufficient.
Caution:
practitioners may want to test for antibodies if they suspect Hashimoto's Disease.
Warning:
Not suitable for patients with Hyperthyroidism, Pituitary tumors, Grave's disease.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
L-Tyrosine
Several enzymes related to tyrosine metabolism in the body have been found to be correlated to hypothyroidism. The inhibition of tyrosine kinase, through agents such as sunitinib and sorafenib induces hypothyroidism through reduction of TSH, through a mechanism, which is thought to block iodine uptake (Mannavola et al, 2007 & Torino et al, 2009). Alterations in tyrosine hydroxylase activity have also been correlated to hypothyroidism in rats, suggesting it has a regulatory influence on the thyroid hormone (Rastogi & Singhal, 1974).*
Coleus Forskohlii (20% extract of Forskolin)
In traditional Chinese medicine, Coleus forskohlii has been thought to be a treatment for hypothyroidism, though clinical testing has been inconclusive (Yarnell & Abascal, 2006). The chemically active ingredient in the herb is forskolin, and there is here is evidence suggesting it may increase thyroid through the activation of the beta-naphthylamidase enzyme which functions to raise cyclic adenosine monophosphate (cAMP) levels, a key cell-regulating substance. This in turn stimulates the release of thyroid hormone (TSH), relieving symptoms of hypothyroidism such as fatigue, depression, weight gain and dry skin. This activity has been shown through cytochemical bioassays in guinea pig thyroid sections. Though the exact location of the forskolin action is not known, this study provided evidence that forskolin acted at a post-surface receptor site (Ealey, 1985).*
Forskolin
Forskolin is an extract of an Ayurvedic herb that resensitizes cell receptors by activating the enzyme adenylcyclase and increasing the levels of cyclic AMP in cells. Cyclic AMP is an important signal carrier that is necessary for the proper biological response of cells to hormones. It is required for cell communication in the hypothalamus/pituitary gland axis and for the feedback control of hormones, including thyroid, HGH, Cortisol, DHEA, Testosterone, and Melatonin.*
Forskolin stimulation of naphthylamidase in guinea pig thyroid sections detected with a cytochemical bioassay.
Ealey PA, Kohn LD, Marshall NJ, Ekins RP. Acta Endocrinol (Copenh). 1985 Mar;108(3):367-71.
Forskolin, from the roots of the Indian medicinal plant Coleus forskohlii, has recently been shown to be a potent stimulator of adenylate cyclase in many systems, including endocrine tissues such as the thyroid gland. We describe forskolin activation of beta-naphthylamidase activity in guinea pig thyroid tissue using the cytochemical bioassay (CBA) for thyroid stimulators. This CBA is the most sensitive bioassay for TSH and LATS-B currently available, being able to detect stimulation by doses as low as 10(-5) mU TSH/l and 10(-9) mU LATS-B/l. The dose-response curve to forskolin was bell-shaped (as is seen with TSH and LATS-B) with the ascending limb of the curve produced by 10(-13) M to 10(-12) M forskolin after a 3 min exposure time. Maximal stimulation was observed with 10(-12) M forskolin. However, the dose-response curve to forskolin was not parallel to that given by TSH, the slope of the ascending limb being much greater. It has been suggested that stimulation of beta-naphthylamidase activity in the CBA is via cAMP. We report that dibutyryl cAMP at doses from 10(-16) M to 10(-11) M produces a bell-shaped dose-response curve with a very broad peak response, again not parallel to that produced by TSH. Forskolin activation of beta-naphthylamidase in the CBA is unaffected by a 1:10(6) dilution of 11E8, a monoclonal antibody raised against solubilized TSH receptors, which binds to the TSH receptor and inhibits TSH stimulation. Although the precise location of forskolin action is not known, this is further evidence that forskolin acts at a post-surface receptor site.*
Cordyceps (0.15% adenosine & 5% mannitol)
The hot water extract of Cordyceps sinensis has been found to have anti-fatigue and anti-stress actions in mice and rats, as well as suppress weight changes in the adrenal gland, spleen, thymus and thyroid. It has also been found to significantly inhibit increases in total cholesterol in rats (Koh et al, 2003). *
Anti-fatigue and anti-stress effect of the hot-water fraction from mycelia of Cordyceps sinensis.
Koh JH, Kim KM, Kim JM, Song JC, Suh HJ. Biol Pharm Bull. 2003 May;26(5):691-4.
This study was conducted to investigate the chemical component of the hot water (HW) fraction of mycelia of Cordyceps sinensis and its anti-fatigue and anti-stress effect against a stimulus in vivo using rats and mice. The growth of mycelia reached a maximum level of 31.6 g/l after 120 h of incubation. The main chemical composition of the HW fraction of mycelia of C. sinensis was found to be carbohydrate (78.9%) with 5% moisture. The swimming endurance capacity of mice orally administered with the HW fraction (150 and 300 mg/kg/d, respectively) was significantly prolonged from 75 to 90 min with a lessening of fatigue. When the HW fraction (150 mg/kg/d) was given to rats for 8 d including a 48 h stress period, the weight changes of the adrenal gland, spleen, thymus, and thyroid, which is an index of stress, were suppressed. The HW fraction also significantly inhibited the increase in total cholesterol and the decrease in alkaline phosphatase levels as biochemical parameters of immobilization stress in rats.*
Guggul (guggulipid extract standardized to 10% guggulsterones, containing 0.5-2%E- and Z-guggulsterones.)
Guggul is a herbal extract from resin of the Commiphora mukul tree widely used in Asia as a cholesterol-lowering agent. Guggulsterones, the presumed bioactive compounds of guggul, are thought to antagonize two nuclear hormone receptors involved in cholesterol metabolism and induce the hypolipidemic effects seen in these extracts (Nohr et al, 2009). Scientific clinical trials investigating this extract have been inconclusive, with some studies finding cholesterol-lowering effects, and other research suggesting no benefits (Ulbricht et al, 2005).*
References
Ealey, P.A., Kohn L.D., Marshall N.J., Ekins R.P. (1985) Acta Endocrinol (Copenh)., 108(3):367-71.
Koh, J.H., Kim, K.M., Kim, J.M., Song, J.C., Suh, H.J. (2003) Biol Pharm Bull. 26(5):691-4.
Mannavola, D., Coco, P., Vannucchi, G., Bertuelli, R., Carletto, M., Casali, P. G., et al. (2007). A Novel Tyrosine-Kinase Selective Inhibitor, Sunitinib, Induces Transient Hypothyroidism by Blocking Iodine Uptake. Journal of Clinical Endocrinology & Metabolism, 92(9), 3531-3534.
Nohr, L. A., Rasmussen, L. B. R., & Straand, J. R. (2009). Resin from the mukul myrrh tree, guggul, can it be used for treating hypercholesterolemia? A randomized, controlled study. Complementary Therapies in Medicine, 17(1), 16-22.
Rastogi, R. B., & Singhal, R. L. (1974). Alterations in brain norepinephrine and tyrosine hydroxylase activity during experimental hypothyroidism in rats. Brain Research, 81(2), 253-266.
Torino, F., Corsello, S. M., Longo, R., Barnabei, A., & Gasparini, G. (2009). Hypothyroidism related to tyrosine kinase inhibitors: an emerging toxic effect of targeted therapy. Nat Rev Clin Oncol, 6(4), 219-228.
Ulbricht, C., Basch, E., Szapary, P., Hammerness, P., Axentsev, S., Boon, H., et al. (2005). Guggul for hyperlipidemia: A review by the Natural Standard Research Collaboration. Complementary Therapies in Medicine, 13(4), 279-290.
Yarnell, E., & Abascal, K. (2006). Botanical Medicine for Thyroid Regulation. Alternative and Complementary Therapies, 12(3), 107-112.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Supplement FactsServing Size:2 capsules Servings Per Container: 30 |
||
|---|---|---|
|
Amount Per Serving |
% Daily Value |
|
| L-Tyrosine | 350 mg | † |
| Coleus Forskohlii (contains forskolin) | 150mg | † |
| Cordyceps (contains adenosine and mannitol) (Dong Chong Xia Cao) | 340mg | † |
| Guggulipid (contains guggulsterones, E- and Z-guggulsterones) | 160mg | † |
| † Daily Value not established. | ||
Other Ingredients: Vegetable cellulose (hypromellose); Vegetable Stearic Acid; Microcrystalline Cellulose and Vegetable Magnesium Stearate.
Does Not Contain: Wheat, gluten, soy, milk, eggs, fish, crustacean shellfish, tree nuts, peanuts
ThyroCaps
60 x 500mg Vegetarian Capsules
Product Overview
Hypothyroidism, also called under-active thyroid or low thyroid, is a common disorder of the endocrine system. It can cause a number of symptoms, intolerance of cold, fatigue, insomnia, constipation, depression, poor concentration, lowered metabolism, increased menstrual flow, slow heart rate and weight gain. These are very common symptoms but hypothyroidism itself is often undiagnosed. Causes include low iodine levels or Hashimoto's thyroiditis, an autoimmune disease. While the test usually used to diagnose is measuring thyroid-stimulating hormone (TSH), it is not always accurate.*
ThyroCaps supplies L-Tyrosine for thyroxine production, increases thyroxine production, increases T4 to T3 conversion and increases thermogenesis. Among other ingredients ThyroCaps contains an extract of Coleus forskohlii called forskolin, which stimulates the release the thyroid, relieving fatigue, depression, weight gain, and dry skin. Specifically, forskolin is thought to increase thyroid function by activating an enzyme that raises levels of a key cell-regulating substance called cAMP (cyclic adenosine monophosphate).*
Actions
•Supports optimum hormone balance*
•Encourages healthy cellular metabolism*
Suggested Use:
1 to 2 capsules 1 to 2 times daily, maximum 4 daily. Generally, 2 capsules daily is sufficient.
Caution:
practitioners may want to test for antibodies if they suspect Hashimoto's Disease.
Warning:
Not suitable for patients with Hyperthyroidism, Pituitary tumors, Grave's disease.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
L-Tyrosine
Several enzymes related to tyrosine metabolism in the body have been found to be correlated to hypothyroidism. The inhibition of tyrosine kinase, through agents such as sunitinib and sorafenib induces hypothyroidism through reduction of TSH, through a mechanism, which is thought to block iodine uptake (Mannavola et al, 2007 & Torino et al, 2009). Alterations in tyrosine hydroxylase activity have also been correlated to hypothyroidism in rats, suggesting it has a regulatory influence on the thyroid hormone (Rastogi & Singhal, 1974).*
Coleus Forskohlii (20% extract of Forskolin)
In traditional Chinese medicine, Coleus forskohlii has been thought to be a treatment for hypothyroidism, though clinical testing has been inconclusive (Yarnell & Abascal, 2006). The chemically active ingredient in the herb is forskolin, and there is here is evidence suggesting it may increase thyroid through the activation of the beta-naphthylamidase enzyme which functions to raise cyclic adenosine monophosphate (cAMP) levels, a key cell-regulating substance. This in turn stimulates the release of thyroid hormone (TSH), relieving symptoms of hypothyroidism such as fatigue, depression, weight gain and dry skin. This activity has been shown through cytochemical bioassays in guinea pig thyroid sections. Though the exact location of the forskolin action is not known, this study provided evidence that forskolin acted at a post-surface receptor site (Ealey, 1985).*
Forskolin
Forskolin is an extract of an Ayurvedic herb that resensitizes cell receptors by activating the enzyme adenylcyclase and increasing the levels of cyclic AMP in cells. Cyclic AMP is an important signal carrier that is necessary for the proper biological response of cells to hormones. It is required for cell communication in the hypothalamus/pituitary gland axis and for the feedback control of hormones, including thyroid, HGH, Cortisol, DHEA, Testosterone, and Melatonin.*
Forskolin stimulation of naphthylamidase in guinea pig thyroid sections detected with a cytochemical bioassay.
Ealey PA, Kohn LD, Marshall NJ, Ekins RP. Acta Endocrinol (Copenh). 1985 Mar;108(3):367-71.
Forskolin, from the roots of the Indian medicinal plant Coleus forskohlii, has recently been shown to be a potent stimulator of adenylate cyclase in many systems, including endocrine tissues such as the thyroid gland. We describe forskolin activation of beta-naphthylamidase activity in guinea pig thyroid tissue using the cytochemical bioassay (CBA) for thyroid stimulators. This CBA is the most sensitive bioassay for TSH and LATS-B currently available, being able to detect stimulation by doses as low as 10(-5) mU TSH/l and 10(-9) mU LATS-B/l. The dose-response curve to forskolin was bell-shaped (as is seen with TSH and LATS-B) with the ascending limb of the curve produced by 10(-13) M to 10(-12) M forskolin after a 3 min exposure time. Maximal stimulation was observed with 10(-12) M forskolin. However, the dose-response curve to forskolin was not parallel to that given by TSH, the slope of the ascending limb being much greater. It has been suggested that stimulation of beta-naphthylamidase activity in the CBA is via cAMP. We report that dibutyryl cAMP at doses from 10(-16) M to 10(-11) M produces a bell-shaped dose-response curve with a very broad peak response, again not parallel to that produced by TSH. Forskolin activation of beta-naphthylamidase in the CBA is unaffected by a 1:10(6) dilution of 11E8, a monoclonal antibody raised against solubilized TSH receptors, which binds to the TSH receptor and inhibits TSH stimulation. Although the precise location of forskolin action is not known, this is further evidence that forskolin acts at a post-surface receptor site.*
Cordyceps (0.15% adenosine & 5% mannitol)
The hot water extract of Cordyceps sinensis has been found to have anti-fatigue and anti-stress actions in mice and rats, as well as suppress weight changes in the adrenal gland, spleen, thymus and thyroid. It has also been found to significantly inhibit increases in total cholesterol in rats (Koh et al, 2003). *
Anti-fatigue and anti-stress effect of the hot-water fraction from mycelia of Cordyceps sinensis.
Koh JH, Kim KM, Kim JM, Song JC, Suh HJ. Biol Pharm Bull. 2003 May;26(5):691-4.
This study was conducted to investigate the chemical component of the hot water (HW) fraction of mycelia of Cordyceps sinensis and its anti-fatigue and anti-stress effect against a stimulus in vivo using rats and mice. The growth of mycelia reached a maximum level of 31.6 g/l after 120 h of incubation. The main chemical composition of the HW fraction of mycelia of C. sinensis was found to be carbohydrate (78.9%) with 5% moisture. The swimming endurance capacity of mice orally administered with the HW fraction (150 and 300 mg/kg/d, respectively) was significantly prolonged from 75 to 90 min with a lessening of fatigue. When the HW fraction (150 mg/kg/d) was given to rats for 8 d including a 48 h stress period, the weight changes of the adrenal gland, spleen, thymus, and thyroid, which is an index of stress, were suppressed. The HW fraction also significantly inhibited the increase in total cholesterol and the decrease in alkaline phosphatase levels as biochemical parameters of immobilization stress in rats.*
Guggul (guggulipid extract standardized to 10% guggulsterones, containing 0.5-2%E- and Z-guggulsterones.)
Guggul is a herbal extract from resin of the Commiphora mukul tree widely used in Asia as a cholesterol-lowering agent. Guggulsterones, the presumed bioactive compounds of guggul, are thought to antagonize two nuclear hormone receptors involved in cholesterol metabolism and induce the hypolipidemic effects seen in these extracts (Nohr et al, 2009). Scientific clinical trials investigating this extract have been inconclusive, with some studies finding cholesterol-lowering effects, and other research suggesting no benefits (Ulbricht et al, 2005).*
References
Ealey, P.A., Kohn L.D., Marshall N.J., Ekins R.P. (1985) Acta Endocrinol (Copenh)., 108(3):367-71.
Koh, J.H., Kim, K.M., Kim, J.M., Song, J.C., Suh, H.J. (2003) Biol Pharm Bull. 26(5):691-4.
Mannavola, D., Coco, P., Vannucchi, G., Bertuelli, R., Carletto, M., Casali, P. G., et al. (2007). A Novel Tyrosine-Kinase Selective Inhibitor, Sunitinib, Induces Transient Hypothyroidism by Blocking Iodine Uptake. Journal of Clinical Endocrinology & Metabolism, 92(9), 3531-3534.
Nohr, L. A., Rasmussen, L. B. R., & Straand, J. R. (2009). Resin from the mukul myrrh tree, guggul, can it be used for treating hypercholesterolemia? A randomized, controlled study. Complementary Therapies in Medicine, 17(1), 16-22.
Rastogi, R. B., & Singhal, R. L. (1974). Alterations in brain norepinephrine and tyrosine hydroxylase activity during experimental hypothyroidism in rats. Brain Research, 81(2), 253-266.
Torino, F., Corsello, S. M., Longo, R., Barnabei, A., & Gasparini, G. (2009). Hypothyroidism related to tyrosine kinase inhibitors: an emerging toxic effect of targeted therapy. Nat Rev Clin Oncol, 6(4), 219-228.
Ulbricht, C., Basch, E., Szapary, P., Hammerness, P., Axentsev, S., Boon, H., et al. (2005). Guggul for hyperlipidemia: A review by the Natural Standard Research Collaboration. Complementary Therapies in Medicine, 13(4), 279-290.
Yarnell, E., & Abascal, K. (2006). Botanical Medicine for Thyroid Regulation. Alternative and Complementary Therapies, 12(3), 107-112.
*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.