Core)Ease

$25.10
PAN102

Core)Ease Is a unique blend of anti-inflammatory and carminative ingredients for treatment of chronic and acute gastric disease, including Gastritis & GERD.*

Supplement Facts

Serving Size: 2 capsule

Servings Per Container: 30

Amount Per Serving

% Daily Value

Rhizoma Atractylodis (Cang Zhu) 232mg
Pericarpium Citri (Chen Pi) 160mg
Cortex Magnoliae Officinalis (Hou Po) 112mg
Zingiberis Rhizoma Recen (Sheng Jiang) 112mg
Zizyphi Fructus (Da Zao) 112mg
Radix Glycyrrhizae (Gan Cao) 72mg
Hesperidin 40mg
Glycyrrhizin 60 mg
6-gingerol 40 mg
Magnolol 60 mg
† Daily Value not established.
Other Ingredients: Vegetable cellulose (hypromellose); Vegetable Stearic Acid; Microcrystalline Cellulose and Vegetable Magnesium Stearate.
DOES NOT CONTAIN: Wheat, gluten, soy, milk, eggs, fish, crustacean shellfish, tree nuts, peanuts

Core)Ease

 60 x 500mg capsules

Product Overview

Core)Ease is based on a classical Chinese formula sometimes referred to as ‘Calm the Stomach Powder.’ The traditional actions are 'to harmonise the Stomach, regulate Qi, tonify Spleen-Qi and Transform Damp-turbidity’. Traditionally it has been employed in the management of gastrointestinal and gynecological presentations. The herbs help act on the whole digestive system, removing obstruction and stagnation by elimination via the intestines.*

Core)Ease supports female reproductive health through encouraging regulation of the menstrual cycle.  TCM pattern 'Regulating spleen qi' supports fluid metabolism and optimum lymphatic function.*

Action

Supports gastrointestinal health*

Supports healthy inflammatory response*

Supports optimum female reproductive health*

Encourages healthy fluid metabolism*

Suggested Use: 

2 to 4 daily, may be increased in acute stages.

Caution:

 none noted

Warning: 

none noted

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Core)ease possesses anti-inflammatory activities via decreasing production of pro-inflammatory mediators through suppression of the signaling pathways of NF-B, TNF, IL-6, COX-2 and MAPKs in LPS-induced macrophage cells. More importantly, results demonstrate a powerful anti-oedema effect (Cha et al, 2013).*

Digestion Calming Formula (Ping Wei San / Calm the Stomach) is based on a traditional basic herbal formula used as a remedy for common gastrointestinal disorders, like gastritis, oesophageal reflux, gastric or duodenal ulcers, and acute or chronic enteritis (Riedlinger, Tan & Lu, 2001; Shin et al, 2011). In addition, this formula is also prescribed for treatment of gynaecological disorders such as amenorrhea, premenstrual syndrome, and cervicitis. Several studies have also reported on the use of Ping Wei San for treatment of eczema, pertussis, reduced libido in men, erectile dysfunction, and halitosis (Scheid & Bensky, 2009).*

In addition, results of different antioxidant tests, including 1, 1-diphenyl-2picryl-hydrazyl (DPPH) radical scavenging, superoxide anion radical scavenging, metal chelating, hydrogen peroxide scavenging, lipid peroxidation protective effect, and scavenging effect of nitric oxide and peroxynitrite have demonstrated the antioxidative activities of Balanced Centre (Yi & Moon, 2007). In addition, Seo et al, 2011 reported that Balanced Centre exhibited anti-inflammatory activity, mainly through inhibition of PGE2 production.*

However, the molecular action and mechanism behind anti-inflammatory activities of PWS have not been elucidated. Therefore, we investigated the effects of PWS on NF-κB and MAPKs signaling pathways and NF-κB-regulated induction of COX-2, iNOS, and pro-inflammatory cytokines in macrophages. In addition, the effects of Balanced Centre on the carrageenan-induced acute oedematous inflammation were evaluated by histopathology and histomorphometry.*

In particular, effects on the changes of total skin thicknesses (from epidermis to dermis), infiltrated inflammatory and mast cell numbers, and COX-2, iNOS, and TNF-α-positive cell numbers were also observed in the present study. These results provide a basis for the molecular mechanism for understanding the effects of Balanced Centre on inflammation.*

References

Cha J Y, Jung Ji Yun, Jung Jae Yup, Lee J R, Cho I J, Ku S K, Byun S H, Ahn TI, Lee C W, Kim S W, and  An W G. Inhibitory Effects of Traditional Herbal Formula Pyungwi-San on Inflammatory Response In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine Volume 2013, Article ID 630198, 19 pages

Riedlinger J. E, Tan P. W, and Lu W., “Pyungwi-san, a Chinese medicine for gastrointestinal disorders,” Annals of Pharmacotherapy, vol. 35, no. 2, pp. 228–235, 2001.

Scheid V, Bensky D, Ellis A, and Barolet R. Chinese Herbal Medicine Formulas & Strategies, Eastland Press, Seattle, Wash, USA, 2009

Seo C. S., Lee J. A., Jung D. et al., “Simultaneous determination of liquiritin, hesperidin, and glycyrrhizin by HPLC-photodiode array detection and the anti-inflammatory effect of Pyungwi-san,” Archives of Pharmacal Research, vol. 34, no. 2, pp. 203–210, 2011.

Shin I. S, Seo C. S, Ha H. K. et al, “Genotoxicity assessment of Pyungwi-san (PWS), a traditional herbal prescription,” Journal of Ethnopharmacology, vol. 133, no. 2, pp. 696–703, 2011.

Yi H. S. and Moon J. Y, “Scavenging property of Pyungwi-san herbal-acupuncture solution on ROS and RNS,” Korean Journal of Oriental Physiology and Pathology, vol. 21, pp. 165–170, 2007.

Core)ease possesses anti-inflammatory activities via decreasing production of pro-inflammatory mediators through suppression of the signaling pathways of NF-B, TNF, IL-6, COX-2 and MAPKs in LPS-induced macrophage cells. More importantly, results demonstrate a powerful anti-oedema effect (Cha et al, 2013).*

Digestion Calming Formula (Ping Wei San / Calm the Stomach) is based on a traditional basic herbal formula used as a remedy for common gastrointestinal disorders, like gastritis, oesophageal reflux, gastric or duodenal ulcers, and acute or chronic enteritis (Riedlinger, Tan & Lu, 2001; Shin et al, 2011). In addition, this formula is also prescribed for treatment of gynaecological disorders such as amenorrhea, premenstrual syndrome, and cervicitis. Several studies have also reported on the use of Ping Wei San for treatment of eczema, pertussis, reduced libido in men, erectile dysfunction, and halitosis (Scheid & Bensky, 2009).*

In addition, results of different antioxidant tests, including 1, 1-diphenyl-2picryl-hydrazyl (DPPH) radical scavenging, superoxide anion radical scavenging, metal chelating, hydrogen peroxide scavenging, lipid peroxidation protective effect, and scavenging effect of nitric oxide and peroxynitrite have demonstrated the antioxidative activities of Balanced Centre (Yi & Moon, 2007). In addition, Seo et al, 2011 reported that Balanced Centre exhibited anti-inflammatory activity, mainly through inhibition of PGE2 production.*

However, the molecular action and mechanism behind anti-inflammatory activities of PWS have not been elucidated. Therefore, we investigated the effects of PWS on NF-κB and MAPKs signaling pathways and NF-κB-regulated induction of COX-2, iNOS, and pro-inflammatory cytokines in macrophages. In addition, the effects of Balanced Centre on the carrageenan-induced acute oedematous inflammation were evaluated by histopathology and histomorphometry.*

In particular, effects on the changes of total skin thicknesses (from epidermis to dermis), infiltrated inflammatory and mast cell numbers, and COX-2, iNOS, and TNF-α-positive cell numbers were also observed in the present study. These results provide a basis for the molecular mechanism for understanding the effects of Balanced Centre on inflammation.*

References

Cha J Y, Jung Ji Yun, Jung Jae Yup, Lee J R, Cho I J, Ku S K, Byun S H, Ahn TI, Lee C W, Kim S W, and  An W G. Inhibitory Effects of Traditional Herbal Formula Pyungwi-San on Inflammatory Response In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine Volume 2013, Article ID 630198, 19 pages

Riedlinger J. E, Tan P. W, and Lu W., “Pyungwi-san, a Chinese medicine for gastrointestinal disorders,” Annals of Pharmacotherapy, vol. 35, no. 2, pp. 228–235, 2001.

Scheid V, Bensky D, Ellis A, and Barolet R. Chinese Herbal Medicine Formulas & Strategies, Eastland Press, Seattle, Wash, USA, 2009

Seo C. S., Lee J. A., Jung D. et al., “Simultaneous determination of liquiritin, hesperidin, and glycyrrhizin by HPLC-photodiode array detection and the anti-inflammatory effect of Pyungwi-san,” Archives of Pharmacal Research, vol. 34, no. 2, pp. 203–210, 2011.

Shin I. S, Seo C. S, Ha H. K. et al, “Genotoxicity assessment of Pyungwi-san (PWS), a traditional herbal prescription,” Journal of Ethnopharmacology, vol. 133, no. 2, pp. 696–703, 2011.

Yi H. S. and Moon J. Y, “Scavenging property of Pyungwi-san herbal-acupuncture solution on ROS and RNS,” Korean Journal of Oriental Physiology and Pathology, vol. 21, pp. 165–170, 2007.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.